Giuseppe Nicosia, Optimization, Combinatorial Optimization, Numerical Optimization, Non Linear Optimization, Large Scale Optimization, Evolutionary Algorithms, Genetic Algorithms, Immune Algorithms, Artificial Immune Systems, Graph Coloring, String Folding, NP-complete problems, Circuit Optimization, Circuit Design, Design For Yield, Device Optimization, Bioinformatics, Structural Bioinformatics, Protein Folding, Protein Structure Prediction, HP model.